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From the dawn of life itself, every being that has ever lived owes its existence to the cell.
The discovery of this vital form led to a transformation in medicine but also in our understanding of ourselves - not as bodies or machines but as ecosystems. It has also given us the power to treat a vast array of mortal maladies...and even to create new kinds of human altogether.
Rich with stories of scientists, doctors and the patients whose lives may be saved by their work, The Song of the Cell is a stunning ode to the building blocks of life and the cutting-edge science harnessing their power for the better.
Winner of the 2023 PROSE Award for Excellence in Biological and
Life Sciences and the 2023 Chautauqua Prize! Named a New York Times
Notable Book and a Best Book of the Year by The Economist, Oprah
Daily, BookPage, Book Riot, the New York Public Library, and more!
In The Song of the Cell, the extraordinary author of the Pulitzer
Prize-winning The Emperor of All Maladies and the #1 New York Times
bestseller The Gene "blends cutting-edge research, impeccable
scholarship, intrepid reporting, and gorgeous prose into an
encyclopedic study that reads like a literary page-turner" (Oprah
Daily). Mukherjee begins this magnificent story in the late 1600s,
when a distinguished English polymath, Robert Hooke, and an
eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down
their handmade microscopes. What they saw introduced a radical
concept that swept through biology and medicine, touching virtually
every aspect of the two sciences, and altering both forever. It was
the fact that complex living organisms are assemblages of tiny,
self-contained, self-regulating units. Our organs, our physiology,
our selves--hearts, blood, brains--are built from these
compartments. Hooke christened them "cells." The discovery of
cells--and the reframing of the human body as a cellular
ecosystem--announced the birth of a new kind of medicine based on
the therapeutic manipulations of cells. A hip fracture, a cardiac
arrest, Alzheimer's dementia, AIDS, pneumonia, lung cancer, kidney
failure, arthritis, COVID pneumonia--all could be reconceived as
the results of cells, or systems of cells, functioning abnormally.
And all could be perceived as loci of cellular therapies. Filled
with writing so vivid, lucid, and suspenseful that complex science
becomes thrilling, The Song of the Cell tells the story of how
scientists discovered cells, began to understand them, and are now
using that knowledge to create new humans. Told in six parts, and
laced with Mukherjee's own experience as a researcher, a doctor,
and a prolific reader, The Song of the Cell is both panoramic and
intimate--a masterpiece on what it means to be human. "In an
account both lyrical and capacious, Mukherjee takes us through an
evolution of human understanding: from the seventeenth-century
discovery that humans are made up of cells to our cutting-edge
technologies for manipulating and deploying cells for therapeutic
purposes" (The New Yorker).
The Song of the Cell is the vivid, thrilling and suspenseful story
of the fundamental unit of life. It describes how scientists
discovered cells, began to understand them, and are now using that
knowledge to create new humans. Both panoramic and intimate, it is
Siddhartha Mukherjee's most spectacular book yet. In the late
1600s, a distinguished English polymath, Robert Hooke, and an
eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, look down
their hand-made microscopes. What they see introduces a radical
concept that alters both biology and medicine forever. It is the
fact that complex living organisms are assemblages of tiny,
self-contained, self-regulating units. Our organs, our physiology,
our selves, are built from these compartments. Hooke christens them
'cells'. The discovery of cells announced the birth of a new kind
of medicine. A hip fracture, a cardiac arrest, Alzheimer's, AIDS,
lung cancer - all could be re-conceived as the results of cells, or
a cellular ecosystem, functioning abnormally. And all could be
treated by therapeutic manipulations of cells. This revolution in
cell biology is still in progress: it represents one of the most
significant advances in science and medicine. Rich with stories of
scientists, doctors, and the patients whose lives may be saved by
their work, The Song of the Cell is the third book in this
extraordinary writer's exploration of what it means to be human.
A magnificent, beautifully written biography of cancer -- from its first documented appearances thousands of years ago through the epic battles to cure, control and conquer it, to a radical new
understanding of its essence.
In The Emperor of All Maladies, Siddhartha Mukherjee, doctor, researcher and award-winning science writer, examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand
years.
The story of cancer is a story of human ingenuity, resilience and perseverance, but also of hubris, arrogance and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out 'war against cancer'. Mukherjee recounts centuries of discoveries, setbacks, victories and deaths, told through the eyes of predecessors and peers, training their wits against an infinitely resourceful adversary.
From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteeth-century recipient of primitive radiation and chemotherapy and Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through toxic, bruising, and draining regimes to survive and to increase the store of human knowledge.
Riveting and magesterial, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments and a brilliant new perspective on the way doctors, scientists,
philosophers and lay people have observed and understood the human body for millennia.
**A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and
GUARDIAN BOOK OF THE YEAR 2022** 'As big a topic as life itself;
I'm not sure a writer could cover it better' The Times From the
prize-winning author of The Emperor of All Maladies, The Song of
the Cell tells the vivid, thrilling and suspenseful story of the
fundamental unit of life. In the late 1600s, a distinguished
English polymath, Robert Hooke, and an eccentric Dutch
cloth-merchant, Antonie van Leeuwenhoek, look down their hand-made
microscopes. What they see introduces a radical concept that alters
both biology and medicine forever. It is the fact that complex
living organisms are assemblages of tiny, self-contained,
self-regulating units. Our organs, our physiology, our selves, are
built from these compartments. Hooke christens them 'cells'. The
discovery of cells announced the birth of a new kind of medicine. A
hip fracture, a cardiac arrest, Alzheimer's, AIDS, lung cancer -
all could be re-conceived as the results of cells, or a cellular
ecosystem, functioning abnormally. And all could be treated by
therapeutic manipulations of cells. This revolution in cell biology
is still in progress: it represents one of the most significant
advances in science and medicine. Both panoramic and intimate, this
is Siddhartha Mukherjee's most spectacular book yet. 'Brilliant ...
medical magic' Daily Telegraph
* Covers the guidelines and standards followed in the industry and
how engineering documents are generated using these standards *
Describes Hazardous Area Classification, Relief System Design,
Revamp Engineering, Interaction with Other Disciplines, and
Pre-commissioning and Commissioning * Contains several illustrated
practical examples, which clarify the fundamentals to a raw
chemical engineer * Includes description of a complete chemical
project from concept to commissioning
Winner of the Pulitzer Prize, and now a documentary from Ken Burns
on PBS, The Emperor of All Maladies is a magnificent, profoundly
humane "biography" of cancer--from its first documented appearances
thousands of years ago through the epic battles in the twentieth
century to cure, control, and conquer it to a radical new
understanding of its essence. Physician, researcher, and
award-winning science writer, Siddhartha Mukherjee examines cancer
with a cellular biologist's precision, a historian's perspective,
and a biographer's passion. The result is an astonishingly lucid
and eloquent chronicle of a disease humans have lived with--and
perished from--for more than five thousand years. The story of
cancer is a story of human ingenuity, resilience, and perseverance,
but also of hubris, paternalism, and misperception. Mukherjee
recounts centuries of discoveries, setbacks, victories, and deaths,
told through the eyes of his predecessors and peers, training their
wits against an infinitely resourceful adversary that, just three
decades ago, was thought to be easily vanquished in an all-out "war
against cancer." The book reads like a literary thriller with
cancer as the protagonist. From the Persian Queen Atossa, whose
Greek slave may have cut off her diseased breast, to the
nineteenth-century recipients of primitive radiation and
chemotherapy to Mukherjee's own leukemia patient, Carla, The
Emperor of All Maladies is about the people who have soldiered
through fiercely demanding regimens in order to survive--and to
increase our understanding of this iconic disease. Riveting,
urgent, and surprising, The Emperor of All Maladies provides a
fascinating glimpse into the future of cancer treatments. It is an
illuminating book that provides hope and clarity to those seeking
to demystify cancer.
** NEW YORK TIMES NUMBER ONE BESTSELLER ** The Gene is the story of
one of the most powerful and dangerous ideas in our history from
the author of The Emperor of All Maladies. The story begins in an
Augustinian abbey in 1856, and takes the reader from Darwin's
groundbreaking theory of evolution, to the horrors of Nazi
eugenics, to present day and beyond - as we learn to "read" and
"write" the human genome that unleashes the potential to change the
fates and identities of our children. Majestic in its scope and
ambition, The Gene provides us with a definitive account of the
epic history of the quest to decipher the master-code that makes
and defines humans - and paints a fascinating vision of both
humanity's past and future. For fans of Sapiens by Yuval Noah
Harari, A Brief History of Time by Stephen Hawking and Being Mortal
by Atul Gwande. 'Siddhartha Mukherjee is the perfect person to
guide us through the past, present, and future of genome science'
Bill Gates 'A thrilling and comprehensive account of what seems
certain to be the most radical, controversial and, to borrow from
the subtitle, intimate science of our time...Read this book and
steel yourself for what comes next' Sunday Times
On 11 March 2020, the WHO declared we were in a pandemic. Covid-19
was tearing through the world at an alarming rate and little was
actually known about it, let alone how to treat it. The majority of
us had paid little attention to the development of a new strain of
coronavirus in China earlier on in the year; however, on 4 January
2020 Justin Stebbing, Professor of Cancer Medicine and Oncology at
Imperial College London, wrote an email to Niall Ferguson
mentioning stories he had heard of strange cases of pneumonia
emanating from Wuhan, China. He then began writing daily notes. In
Witness to Covid: 2020, Professor Justin Stebbing tracks the
development of Covid-19 over the course of this unforgettable year,
navigating his way through the infodemic of misinformation
regarding the virus. From the early onset of this novel coronavirus
when he tracked its spread and tried to learn more about it, the
impact on individual countries and the search for treatment,
through to the development of vaccines, their clinical trials and
eventual rollout, and the emergence of newly developing variants.
This book takes a unique look at a truly unique year.
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